IDMembersPhysical
Score
Correlation
283MGM101 RIM1 RFA1 MSH2 TOP3 SGS1 MPH1 MSH6 RAD52 RFA2
MGM101 MGM9 Protein involved in mitochondrial genome maintenance; component of the mitochondrial nucleoid, required for the repair of oxidative mtDNA damage
RIM1 Single-stranded DNA-binding protein essential for mitochondrial genome maintenance; involved in mitochondrial DNA replication
RFA1 BUF2|FUN3|RPA1 Subunit of heterotrimeric Replication Factor A (RF-A), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination
MSH2 PMS5 Protein that forms heterodimers with Msh3p and Msh6p that bind to DNA mismatches to initiate the mismatch repair process; contains a Walker ATP-binding motif required for repair activity; Msh2p-Msh6p binds to and hydrolyzes ATP
TOP3 EDR1 DNA Topoisomerase III, conserved protein that functions in a complex with Sgs1p and Rmi1p to relax single-stranded negatively-supercoiled DNA preferentially, involved in telomere stability and regulation of mitotic recombination
SGS1 Nucleolar DNA helicase of the RecQ family involved in maintenance of genome integrity, regulates chromosome synapsis and meiotic crossing over; has similarity to human BLM and WRN helicases implicated in Bloom and Werner syndromes
MPH1 Member of the DEAH family of helicases, functions in an error-free DNA damage bypass pathway that involves homologous recombination, mutations confer a mutator phenotype
MSH6 PMS3 Protein required for mismatch repair in mitosis and meiosis, forms a complex with Msh2p to repair both single-base & insertion-deletion mispairs; potentially phosphorylated by Cdc28p
RAD52 Protein that stimulates strand exchange by facilitating Rad51p binding to single-stranded DNA; anneals complementary single-stranded DNA; involved in the repair of double-strand breaks in DNA during vegetative growth and meiosis
RFA2 BUF1|RPA2 Subunit of heterotrimeric Replication Factor A (RF-A), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination
IDMembers# IntsMean Score (FDR)Network
Between Scores
692MUS81 MMS4 20-2.678(1%)
205PFD1 PAC10 YKE2 GIM5 GIM4 GIM3 BUD27 580.5854(.1%)
159PRI1 6-5.240(1%)
413MRC1 10-3.817(1%)
121TSA1 9-3.661(1%)
347POL30 HYS2 POL32 24-2.327(1%)
242AHC1 NUP84 9-3.957(.1%)
511TOF1 CSM3 18-2.815(1%)