IDMembersPhysical
Score
Correlation
456RPB4 RPB3 TFG2 TFG1 DST1 IWR1 RPO21 SPT4
RPB4 CTF15 RNA polymerase II subunit B32; forms two subunit dissociable complex with Rpb7p; dispensable under some environmental conditions; involved in export of mRNA to cytoplasm under stress conditions; involved in telomere maintenance
RPB3 RNA polymerase II third largest subunit B44, part of central core; similar to prokaryotic alpha subunit
TFG2 TFIIF (Transcription Factor II) middle subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP30
TFG1 RAP74|SSU71 TFIIF (Transcription Factor II) largest subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP74
DST1 PPR2 General transcription elongation factor TFIIS, enables RNA polymerase II to read through blocks to elongation by stimulating cleavage of nascent transcripts stalled at transcription arrest sites
IWR1 Protein of unknown function, deletion causes hypersensitivity to the K1 killer toxin
RPO21 RPB1|RPB220|SUA8 RNA polymerase II largest subunit B220, part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime
SPT4 Protein that forms a complex with Spt5p and mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing; in addition, Spt4p is involved in kinetochore function and gene silencing
IDMembers# IntsMean Score (FDR)Network
Between Scores
281THP1 SAC3 14-3.365(.1%)
627CIK1 82.2301(.1%)
424UBP3 BRE5 16-3.332(1%)
567SWC7 SWC5 SWC3 YAF9 ARP6 VPS71 SWR1 VPS72 57-3.036(0.01%)