IDMembersPhysical
Score
Correlation
668PHO23 SAP30 RCO1 CTI6 UME1 UME6 RXT2 RXT3 SIN3 EAF3 DEP1 RPD3 SDS3
PHO23 Probable component of the Rpd3 histone deacetylase complex, involved in transcriptional regulation of PHO5; C-terminus has similarity to human candidate tumor suppressor p33(ING1)
SAP30 Subunit of a histone deacetylase complex, along with Rpd3p and Sin3p, that is involved in silencing at telomeres, rDNA, and silent mating-type loci; involved in telomere maintenance
RCO1 Essential subunit of the histone deacetylase Rpd3S complex; interacts with Eaf3p
CTI6 RXT1 Protein that relieves transcriptional repression by binding to the Cyc8p-Tup1p corepressor and recruiting the SAGA complex to the repressed promoter; contains a PHD finger domain
UME1 WTM3 Negative regulator of meiosis, required for repression of a subset of meiotic genes during vegetative growth, binding of histone deacetylase Rpd3p required for activity, contains a NEE box and a WD repeat motif; homologous with Wtm1p, Wtm2p
UME6 CAR80|NIM2|RIM16 Key transcriptional regulator of early meiotic genes, binds URS1 upstream regulatory sequence, couples metabolic responses to nutritional cues with initiation and progression of meiosis, forms complex with Ime1p, and also with Sin3p-Rpd3p
RXT2 RAF60 Subunit of the histone deacetylase Rpd3L complex; possibly involved in cell fusion and invasive growth
RXT3 Protein of unknown function, may be involved in chromatin silencing
SIN3 CPE1|GAM2|RPD1|SDI1|SDS16|UME4 Component of the Sin3p-Rpd3p histone deacetylase complex, involved in transcriptional repression and activation of diverse processes, including mating-type switching and meiosis; involved in the maintenance of chromosomal integrity
EAF3 Esa1p-associated factor, nonessential component of the NuA4 acetyltransferase complex, homologous to Drosophila dosage compensation protein MSL3
DEP1 FUN54 Transcriptional modulator involved in regulation of structural phospholipid biosynthesis genes and metabolically unrelated genes, as well as maintenance of telomeres, mating efficiency, and sporulation
RPD3 MOF6|REC3|SDI2|SDS6 Histone deacetylase; regulates transcription and silencing
SDS3 Component of the Rpd3p/Sin3p deacetylase complex required for its structural integrity and catalytic activity, involved in transcriptional silencing and required for sporulation; cells defective in SDS3 display pleiotropic phenotypes
IDMembers# IntsMean Score (FDR)Network
Between Scores
621VID22 TBF1 YGR071C 351.2406(0.01%)
199YFR038W 131.4912(.1%)
451SAS5 SAS4 SAS2 38-2.398(0.01%)
337GET2 13-5.208(0.01%)
552OPI3 12-4.404(0.01%)
393SKI8 SKI3 SKI2 YKL023W 470.4859(1%)
62GTR1 121.7768(0.01%)
274ELP3 ELP6 ELP4 IKI3 ELP2 IKI1 70-1.822(0.01%)
595VPS21 12-4.230(0.01%)
172SHP1 DOA1 25-2.348(1%)
482TIM18 13-4.639(0.01%)
341TIM13 13-6.106(0.01%)
401IES3 IES5 IES4 NHP10 INO80 IES1 IES2 RVB2 RVB1 ARP8 TAF14 126-1.313(0.01%)
325SGO1 10-4.099(1%)
281THP1 SAC3 26-4.172(0.01%)
738NUP133 12-3.321(1%)
155RGP1 RIC1 201.6215(0.01%)
282YJR087W 12-3.646(1%)
425MBP1 SWI4 SWI6 33-2.234(.1%)
653SEC22 12-8.295(0.01%)
309MMR1 131.2761(1%)
203MSI1 RLF2 CAC2 380.6709(1%)
531CLA4 12-4.136(0.01%)
610SRP40 131.3727(1%)
611SNT1 HST1 HOS4 HOS2 SET3 SIF2 CPR1 88-2.642(0.01%)
672SCS7 10-4.192(1%)
567SWC7 SWC5 SWC3 YAF9 ARP6 VPS71 SWR1 VPS72 99-6.400(0.01%)
77YPT6 131.7783(0.01%)
240YPL113C 111.4794(1%)
627CIK1 13-5.176(0.01%)
242AHC1 NUP84 20-2.9(1%)
115GAL11 MED4 SSN2 SSN3 SIN4 SOH1 SSN8 ROX3 MED2 MED11 MED1 NUT1 PGD1 CSE2 MED8 SRB2 SRB8 189-1.010(0.01%)
94RPN2 POL4 RPN6 UBP6 GSG1 ECM29 RPN13 RPN10 HEX3 SEM1 116-1.296(0.01%)
736CSF1 13-5.073(0.01%)
36LGE1 BRE1 25-4.420(0.01%)
34VPS8 12-4.27(0.01%)
641TAF7 TAF6 TAF5 TAF4 TAF1 SPT8 UBP8 HFI1 SGF29 SGF73 TAF13 TAF12 TAF9 NGG1 SPT3 SGF11 GCN5 184-0.835(.1%)
518UBA3 132.452(0.01%)
327MUB1 RAD18 RAD6 360.6829(1%)
644INO4 122.5359(0.01%)
298NAP1 HTZ1 25-2.558(.1%)
418BIM1 13-3.322(1%)
722FUS3 111.6821(.1%)
517VPS64 HCS1 231.5547(0.01%)
385LRP1 RRP6 250.9401(1%)