IDMembersPhysical
Score
Correlation
739CTF3 MCM16 MCM21 CHL4 MCM22 CTF19 IML3
CTF3 CHL3 Outer kinetochore protein that forms a complex with Mcm16p and Mcm22p; may bind the kinetochore to spindle microtubules
MCM16 Protein involved in kinetochore-microtubule mediated chromosome segregation; binds to centromere DNA
MCM21 CTF5 Protein involved in minichromosome maintenance; component of the COMA complex (Ctf19p, Okp1p, Mcm21p, Ame1p) that bridges kinetochore subunits that are in contact with centromeric DNA and the subunits bound to microtubules
CHL4 CTF17|MCM17 Outer kinetochore protein required for chromosome stability, interacts with kinetochore proteins Ctf19p, Ctf3p, and Iml3p; exhibits a two-hybrid interaction with Mif2p; association with CEN DNA requires Ctf19p
MCM22 Protein involved in minichromosome maintenance; component of the kinetochore; binds to centromeric DNA in a Ctf19p-dependent manner
CTF19 MCM18 Outer kinetochore protein, required for accurate mitotic chromosome segregation; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) that functions as a platform for kinetochore assembly
IML3 MCM19 Protein with a role in kinetochore function, localizes to the outer kinetochore in a Ctf19p-dependent manner, interacts with Chl4p and Ctf19p
IDMembers# IntsMean Score (FDR)Network
Between Scores
627CIK1 7-11.62(0.01%)
249MAD2 MAD1 13-9.593(0.01%)
677BUB1 BUB3 14-7.643(0.01%)
567SWC7 SWC5 SWC3 YAF9 ARP6 VPS71 SWR1 VPS72 50-1.539(1%)
115GAL11 MED4 SSN2 SSN3 SIN4 SOH1 SSN8 ROX3 MED2 MED11 MED1 NUT1 PGD1 CSE2 MED8 SRB2 SRB8 810.4830(.1%)
655RAD61 7-10.66(0.01%)
649KAR3 6-7.780(0.01%)
205PFD1 PAC10 YKE2 GIM5 GIM4 GIM3 BUD27 42-3.962(0.01%)
418BIM1 7-12.65(0.01%)