| RPN2 SEN3 Subunit of the 26S proteasome, substrate of the N-acetyltransferase Nat1p
|
| POL4 POLX DNA polymerase IV, undergoes pair-wise interactions with Dnl4p-Lif1p and Rad27p to mediate repair of DNA double-strand breaks by non-homologous end joining (NHEJ); homologous to mammalian DNA polymerase beta
|
| RPN6 NAS4 Essential, non-ATPase regulatory subunit of the 26S proteasome lid required for the assembly and activity of the 26S proteasome; the human homolog (S9 protein) partially rescues Rpn6p depletion
|
| UBP6 Ubiquitin-specific protease situated in the base subcomplex of the 26S proteasome, releases free ubiquitin from branched polyubiquitin chains; deletion causes hypersensitivity to cycloheximide and other toxic compounds
|
| GSG1 MUM1|TRS85 Subunit of TRAPP (transport protein particle), a multi-subunit complex involved in targeting and/or fusion of ER-to-Golgi transport vesicles with their acceptor compartment; protein has late meiotic role, following DNA replication
|
| ECM29 Major component of the proteasome; tethers the proteasome core particle to the regulatory particle, and enhances the stability of the proteasome
|
| RPN13 Subunit of the 19S regulatory particle of the 26S proteasome lid
|
| RPN10 MCB1|SUN1 Non-ATPase base subunit of the 19S regulatory particle (RP) of the 26S proteasome; N-terminus plays a role in maintaining the structural integrity of the RP; binds selectively to polyubiquitin chains; homolog of the mammalian S5a protein
|
| HEX3 SLX5 Protein containing a RING finger domain that interacts with Slx8p; mutant phenotypes and genetic interactions suggest a role in sumoylation and in genome stability
|
| SEM1 DSS1|HOD1 Component of the lid subcomplex of the regulatory subunit of the 26S proteasome; ortholog of human DSS1
|
